Abstract
AbstractThe structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the structure of gangliosides carrying the N-acetyneuraminic acid O-acetylated in position 9, the Neu5,9Ac2, and of gangliosides carrying a sialic acid that forms a lactone ring. Starting from biochemical data we will discuss the possible biochemical role played by these gangliosides in the processes of cell signaling and maintenance of brain functions.
Funder
Università degli Studi di Milano
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference40 articles.
1. Zipkin, I., Mergenhagen, S.E., Kass, R.: The sialic acid content of human saliva. Biochem. Biophys. Res. Commun. 4, 76–78 (1961)
2. Klenk, E.: Contribution to the concept of ganglioside. Hoppe Seylers Z Physiol Chem. 288, 216–220 (1951)
3. Baumann, N., Sonnino, S., Ghidoni, R., Harpin, M.-L., Tettamanti, G.: Étude des gangliosides chez les Souris normales (C57 B1/6J) et quaking. Presence et caractérization d’un ganglioside labile en milieu alcalin. C.R.Acad.Sci.Paris. 286, 1807–1810 (1978)
4. Haverkamp, J., Veh, R.W., Sander, M., Schauer, R., Kamerling, J.P., Vliegenthart, J.F.G.: Hoppe-Seyler’s 2. Physiol. Chem. ; 358: 1609–1612 (1977)
5. Ghidoni, R., Sonnino, S., Tettamanti, G., Baumann, N., Reuter G. and, Schauer, R.: Isolation and characterization of a trisialoganglioside from mouse brain, containing 9-O-acetyl-N-acetylneuraminic acid. J. Biol. Chem. 255, 6990–6995 (1980)