DNMT1 Methylation of LncRNA GAS5 Leads to Cardiac Fibroblast Pyroptosis via Affecting NLRP3 Axis

Author:

She Qian,Shi Peng,Xu Sheng-Song,Xuan Hai-Yang,Tao Hui,Shi Kai-HuORCID,Yang Yan

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference24 articles.

1. Wang, E.Y., N. Rafatian, Y. Zhao, A. Lee, B.F.L. Lai, R.X. Lu, D. Jekic, L. Davenport Huyer, E.J. Knee-Walden, S. Bhattacharya, P.H. Backx, and M. Radisic. 2019. Biowire model of interstitial and focal cardiac fibrosis. ACS Central Science 5 (7): 1146–1158. https://doi.org/10.1021/acscentsci.9b00052.

2. Nagaraju, C.K., E.L. Robinson, M. Abdesselem, S. Trenson, E. Dries, G. Gilbert, S. Janssens, et al. 2019. Myofibroblast phenotype and reversibility of fibrosis in patients with end-stage heart failure. Journal of the American College of Cardiology 73 (18): 2267–2282. https://doi.org/10.1016/j.jacc.2019.02.049.

3. Nakaya, M., K. Watari, M. Tajima, T. Nakaya, S. Matsuda, H. Ohara, H. Nishihara, H. Yamaguchi, A. Hashimoto, M. Nishida, A. Nagasaka, Y. Horii, H. Ono, G. Iribe, R. Inoue, M. Tsuda, K. Inoue, A. Tanaka, M. Kuroda, S. Nagata, H. Kurose, et al. 2017. Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction. The Journal of Clinical Investigation 127 (1): 383–401. https://doi.org/10.1172/JCI83822.

4. Del Re, D.P., D. Amgalan, A. Linkermann, Q. Liu, and R.N. Kitsis. 2019. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiological Reviews 99 (4): 1765–1817. https://doi.org/10.1152/physrev.00022.2018.

5. Caceres, F. T., T. A. Gaspari, C. S. Samuel, and A. A. Pinar. 2019. Serelaxin inhibits the profibrotic TGF-beta1/IL-1beta axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts. FASEB J:fj201901079RR. doi:https://doi.org/10.1096/fj.201901079RR.

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