Continuous Electroencephalogram (cEEG) Findings and Neurodevelopmental Outcomes in Neonates with Congenital Heart Disease (CHD) at 12–24 Months of Age

Author:

Padiyar SwethaORCID,Friedman Neil,Pestana-Knight Elia,Franic Linda,Worley Sarah,Aly Hany

Abstract

Abstract Objective This study aims to assess the role of continuous EEG (cEEG) background patterns and duration of cross-clamp time and cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD) undergoing cardiac surgery and its correlation with abnormal neurodevelopmental outcomes at 12–24 months on Bayley Scales of Infant and Toddler Development (BSID-III). Methods This retrospective cohort study included infants with CHD and cEEG monitoring, who underwent surgery by 44 weeks gestational age. Results 34 patients were included, who were operated at median age − 7 days. Longer duration of cross- camp time was associated with poor language composite scores (LCS) (p value = 0.036). A significant association existed between severity of encephalopathy in 24-hour post-operative period and poor LCS (p value = 0.026). Conclusion Majority of neonates with CHD have below average cognitive, language and motor composite scores on BSID-III. Longer duration of cross-clamp time and severity of encephalopathy during 24-hour post-operative EEG monitoring are associated with poor LCS.

Funder

Wake Forest University

Publisher

Springer Science and Business Media LLC

Reference47 articles.

1. Andropoulos, D. B., Easley, R. B., Brady, K., McKenzie, E. D., Heinle, J. S., Dickerson, H. A., Shekerdemian, L., Meador, M., Eisenman, C., Hunter, J. V., Turcich, M., Voigt, R. G., & Fraser, C. D. (2012). Changing expectations for neurological outcomes after the neonatal arterial switch operation. The Annals of Thoracic Surgery, 94(4), 1250–1256. https://doi.org/10.1016/J.ATHORACSUR.2012.04.050.

2. Andropoulos, D. B., Ahmad, H. B., Haq, T., Brady, K., Stayer, S. A., Meador, M. R., Hunter, J. V., Rivera, C., Voigt, R. G., Turcich, M., He, C. Q., Shekerdemian, L. S., Dickerson, H. A., Fraser, C. D., McKenzie, D., Heinle, E., J. S., & Easley, B., R (2014). The association between brain injury, perioperative anesthetic exposure, and 12-month neurodevelopmental outcomes after neonatal cardiac surgery: A retrospective cohort study. Paediatric Anaesthesia, 24(3), 266–274. https://doi.org/10.1111/PAN.12350.

3. Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C., k., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., Walsh, A. Z., Helmers, S. L., Constantinou, J. E., Carrazana, E. J., Mayer, J. E., Hanley, F. L., Castaneda, A. R., Ware, J. H., & Newburger, J. W. (1995). Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. New England Journal of Medicine. https://doi.org/10.1056/NEJM199503023320901.

4. Bellinger, D. C., Wypij, D., DuPlessis, A. J., Rappaport, L. A., Jonas, R. A., Wernovsky, G., & Newburger, J. W. (2003). Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: The Boston Circulatory Arrest Trial. Journal of Thoracic and Cardiovascular Surgery, 126(5), 1385–1396. https://doi.org/10.1016/S0022-5223(03)00711-6.

5. C., L., A., M., B., R., M.I., S., C., R., C., T., & R., G. (2001). Association between electroencephalographic findings and neurologic status in infants with congenital heart defects. Journal of Child Neurology.

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