Abstract
AbstractGuanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely distributed among eukaryotes. They are interferon (IFN)-inducible guanosine triphosphatases that belong to the dynamin superfamily. GBPs are known to have a major role in the cell-autonomous innate immune response against bacterial, parasitic and viral infections and are also involved in inflammasome activation. Evolutionary studies depicted that GBPs present a pattern of gain and loss of genes in each family with several genes pseudogenized and some genes more divergent, indicative for the birth-and-death evolution process. Most species harbor large GBP gene clusters encoding multiple paralogs. Previous functional studies mainly focused on mouse and human GBPs, but more data are becoming available, broadening the understanding of this multifunctional protein family. In this review, we will provide new insights and give a broad overview about GBP evolution, conservation and their roles in all studied species, including plants, invertebrates and vertebrates, revealing how far the described features of GBPs can be transferred to other species.
Funder
Deutscher Akademischer Austauschdienst
Fundação para a Ciência e a Tecnologia
Deutsche Forschungsgemeinschaft
Ludwig-Maximilians-Universität München
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Immunology,General Medicine,Immunology and Allergy
Cited by
12 articles.
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