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Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance

  • Published:2020-05-28 Issue:6 Volume:38 Page:1707-1716
  • ISSN:0167-6997
  • Container-title:Investigational New Drugs
  • language:en
  • Short-container-title:Invest New Drugs

Author:

Chen Hao,Zhu Xiaoling,Sun Rong,Ma Panpan,Zhang Erhao,Wang Zhou,Fan Yihui,Zhou Guoxiong,Mao Renfang

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference27 articles.

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2. Torres C, Grippo PJ (2018) Pancreatic cancer subtypes: a roadmap for precision medicine. Ann Med 50:277–287. https://doi.org/10.1080/07853890.2018.1453168

3. Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Gu S, Cooc J, Weinkle J, Kim GE, Jakkula L, Feiler HS, Ko AH, Olshen AB, Danenberg KL, Tempero MA, Spellman PT, Hanahan D, Gray JW (2011) Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 17:500–503. https://doi.org/10.1038/nm.2344

4. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321:1801–1806. https://doi.org/10.1126/science.1164368

5. Cheng TY, Yang YC, Wang HP, Tien YW, Shun CT, Huang HY, Hsiao M, Hua KT (2018) Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein. Oncogene 37:1730–1742. https://doi.org/10.1038/s41388-017-0086-y

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