Cytogenetic evolution predicts a poor prognosis in acute myeloid leukemia patients who relapse after allogeneic hematopoietic stem cell transplantation

Author:

Li Ruiqi,Wang Ziwei,Zhang Yuesheng,Guo Mengqiao,Ni Xiong,Chen Jie,Chen Li,Gao Lei,Gong Shenglan,Tang Gusheng,Yang Jianmin,Wang JianminORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference25 articles.

1. Bejanyan N, Oran B, Shanley R, Warlick E, Ustun C, Vercellotti G et al (2014) Clinical outcomes of AML patients relapsing after matched-related donor and umbilical cord blood transplantation. Bone Marrow Transplant 49:1029–1035. https://doi.org/10.1038/bmt.2014.116

2. Schmid C, de Wreede LC, van Biezen A, Finke J, Ehninger G, Ganser A et al (2018) Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation. Haematologica 103:237–245. https://doi.org/10.3324/haematol.2017.168716

3. Shimizu H, Yokohama A, Ishizaki T, Hatsumi N, Takada S, Saitoh T et al (2018) Clonal evolution detected with conventional cytogenetic analysis is a potent prognostic factor in adult patients with relapsed AML. Hematol Oncol 36:252–257. https://doi.org/10.1002/hon.2393

4. Vosberg S, Greif PA (2019) Clonal evolution of acute myeloid leukemia from diagnosis to relapse. Genes Chromosomes Cancer 58:839–849. https://doi.org/10.1002/gcc.22806

5. Onecha E, Rapado I, Morales ML, Carreno-Tarragona G, Martinez-Sanchez P, Gutierrez X et al (2021) Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse. Haematologica 106:2325–2333. https://doi.org/10.3324/haematol.2020.254623

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