A high frequency of Gilbert syndrome (UGT1A1*28/*28) and associated hyperbilirubinemia but not cholelithiasis in adolescent and adult north Indian patients with transfusion-dependent β-thalassemia

Author:

Shrestha Oshan,Khadwal Alka Rani,Singhal Manphool,Trehan Amita,Bansal Deepak,Jain Richa,Pal Arnab,Hira Jasbir Kaur,Chhabra Sanjeev,Malhotra Pankaj,Das ReenaORCID,Sharma PrashantORCID

Funder

Medical Education and Research Cell, PGIMER, Chandigarh

Department of Biotechnology , Ministry of Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference31 articles.

1. Marengo-Rowe AJ (2007) The thalassemias and related disorders. Proc Bayl Univ Med Cent 20:27–31

2. Weatherall DJ, Clegg JB (eds) (2001) The thalassaemia syndromes, ed 4. Blackwell Scientific, Oxford

3. Origa R, Galanello R, Perseu L, Tavazzi D, Cappellini MD, Terenzani L et al (2009) Cholelithiasis in thalassemia major. Eur J Haematol 82:22–25

4. Lotfi M, Keramati P, Assdsangabi R, Nabavizadeh SA, Karimi M (2009) Ultrasonographic assessment of the prevalence of cholelithiasis and biliary sludge in beta-thalassemia patients in Iran. Med Sci Monit Int Med J Exp Clin Res 15:CR398–CR402

5. AlFadhli S, Al-Jafer H, Hadi M, Al-Mutairi M, Nizam R (2013) The effect of UGT1A1 promoter polymorphism in the development of hyperbilirubinemia and cholelithiasis in hemoglobinopathy patients. PLoS ONE 8:e77681

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