Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population
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Published:2024-01-13
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ISSN:1720-8386
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Container-title:Journal of Endocrinological Investigation
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language:en
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Short-container-title:J Endocrinol Invest
Author:
Baenas I., Camacho-Barcia L., Granero R., Razquin C., Corella D., Gómez-Martínez C., Castañer-Niño O., Martínez J. A., Alonso-Gómez Á. M., Wärnberg J., Vioque J., Romaguera D., López-Miranda J., Estruch R., Tinahones F. J., Lapetra J., Serra-Majem J. L., Cano-Ibáñez N., Tur J. A., Martín-Sánchez V., Pintó X., Gaforio J. J., Matía-Martín P., Vidal J., Vázquez C., Daimiel L., Ros E., Jiménez-Murcia S., Dalsgaard S., Garcia-Arellano A., Babio N., Sorli J. V., Lassale C., García-de-la-Hera M., Gómez-García E., Zulet M. A., Konieczna J., Martín-Peláez S., Tojal-Sierra L., Basterra-Gortari F. J., de las Heras-Delgado S., Portoles O., Muñoz-Pérez M. Á., Arenas-Larriva A. P., Compañ-Gabucio L., Eguaras S., Shyam S., Fitó M., Baños R. M., Salas-Salvadó J.ORCID, Fernández-Aranda F.ORCID
Abstract
Abstract
Objectives
To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.
Methods
n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 ± 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.
Results
The presence of T2D increased the likelihood of higher levels of depressive symptoms (χ2 = 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (χ2 = 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c ≥ 7% at 1-year level (Wald-χ2 = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.
Conclusions
This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short–medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.
Funder
Instituto de Salud Carlos III Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus Generalitat Valenciana Generalitat de Catalunya- AGAUR Horizon 2020 Framework Programme Spanish Ministry of Economy, Industry and Competitiveness Universitat Rovira i Virgili Consejería de Salud de la Junta de Andalucía Universitat de Barcelona
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
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