New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression

Author:

Gullo Irene,Oliveira Patrícia,Athelogou Maria,Gonçalves Gilza,Pinto Marta L.,Carvalho Joana,Valente Ana,Pinheiro Hugo,Andrade Sara,Almeida Gabriela M.,Huss Ralf,Das Kakoli,Tan Patrick,Machado José C.,Oliveira Carla,Carneiro FátimaORCID

Funder

European Regional Development Fund (NORTE2020)

Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia (PT)

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Gastroenterology,Oncology,General Medicine

Reference54 articles.

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2. Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 2011;141(2):476–85. https://doi.org/10.1053/j.gastro.2011.04.042 .

3. Duraes C, Almeida GM, Seruca R, Oliveira C, Carneiro F. Biomarkers for gastric cancer: prognostic, predictive or targets of therapy? Virchows Arch. 2014;464(3):367–78. https://doi.org/10.1007/s00428-013-1533-y .

4. Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–97. https://doi.org/10.1016/s0140-6736(10)61121-x .

5. Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2014;383(9911):31–9. https://doi.org/10.1016/s0140-6736(13)61719-5 .

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