HBx mutations emerged during antiviral therapy: a new face of a multifaceted HBV protein?
Author:
Funder
National Major Science and Technology Projects of China
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
Publisher
Springer Science and Business Media LLC
Subject
Hepatology
Link
http://link.springer.com/content/pdf/10.1007/s12072-020-10116-z.pdf
Reference9 articles.
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2. Lin CL, Chien RN, Chu YD, Liang KH, Huang YH, Ke PY, Lin KH, Lin YH, Yeh CT. Hepatitis B virus X gene mutants emerge during antiviral therapy and increase cccDNA levels to compensate for replication suppression. Hepatol Int. 2020. https://doi.org/10.1007/s12072-020-10079-1.
3. Hughes D, Andersson DI. Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms. Nat Rev Genet. 2015;16(8):459–71.
4. Ono SK, Kato N, Shiratori Y, Kato J, Goto T, Schinazi RF, Carrilho FJ, Omata M. The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance. J Clin Investig. 2001;107(4):449–55.
5. Lok AS, Zoulim F, Locarnini S, Bartholomeusz A, Ghany MG, Pawlotsky JM, Liaw YF, Mizokami M, Kuiken C. Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management. Hepatology. 2007;46(1):254–65.
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