Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development-Reference-Cited by-同舟云学术

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Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

Published:2010-10-23 Issue:4 Volume:28 Page:920-933
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

den Engelsman John,Garidel Patrick,Smulders Ronald,Koll Hans,Smith Bryan,Bassarab Stefan,Seidl Andreas,Hainzl Otmar,Jiskoot Wim

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11095-010-0297-1

Reference34 articles.

1. Hermeling S, Crommelin DJA, Schellekens H, Jiskoot W. Structure-immunogenicity relationships of therapeutic proteins. Pharm Res. 2004;21:897–903.

2. Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J. 2006;8(3):E501–7.

3. Chi EY, Krishnan S, Randolph TW, Carpenter JF. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res. 2003;20:1325–39.

4. Mahler HC, Friess W, Grauschopf U, Kiese S. Protein aggregation: pathways, induction factors and analysis. J Pharm Sci. 2009;98:2909–34.

5. Bhatnagar BS, Bogner RH, Pikal MJ. Protein stability during freezing: separation of stresses and mechanisms of protein stabilization. Pharm Dev Technol. 2007;12:505–23.

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