Abstract
Abstract
Purpose:
Diabetic foot ulcers are reported to be the most expensive complications of diabetes, with high morbidity and mortality rates. If the necessary care is not provided for the wound to heal, the individual may end up amputating the affected feet. Photobiomodulation therapy is a promising non-pharmacological treatment option for wound healing. The objective of the present study is to establish a dose-response relationship between photobiomodulation therapy and oxidative stress markers in the healing dynamics of diabetic neuropathic ulcers in Wistar rats.
Methodology:
Diabetic neuropathy was induced in 126 Albino Wistar rats. An excisional wound of an area of 2cm2 was made on the neuropathy-induced leg. Photobiomodulation therapy of dosages 4, 6, 8, 10, 12, and 15 J/cm2 of wavelengths 655 and 808 nm was irradiated. The control group animals were kept un-irradiated. The outcome measures were assessed during wound healing’s inflammatory, proliferative and remodelling phases.
Results:
In the experimental group, animals treated with photobiomodulation therapy at doses of 4, 6, and 8 J/cm2 showed better wound healing dynamics. Photobiomodulation therapy modulated the reactive oxygen species and antioxidant levels, thereby improving the oxidative status of the wound.
Conclusion:
Photobiomodulation therapy of dosages 4, 6, and 8 J/cm2 is effective and is a promising adjuvant modality in treating diabetic neuropathic ulcers. There was a strong dose-response relationship in the experimental groups treated with 4, 6 and 8 J/ cm2.
Funder
Manipal Academy of Higher Education, Manipal
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference26 articles.
1. Tuttolomondo A, Maida C, Pinto A. Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes. World journal of orthopedics. 2015 Jan 18;6 (1):62.
2. Risk assessment of patients with diabetes for foot ulcers according to risk classification consensus of International Working Group on Diabetic Foot (IWGDF). Shahbazian H, Yazdanpanah L, Latifi SM. Pak J Med Sci. 2013 May; 29(3):730–4.
3. World Health Organization. Diagnosis and Management of Type 2 Diabetes (HEARTS-D). World Health Organization: Geneva, Switzerland. 2020. WHO/UCN/NCD/20.1). Licence: CC BY-NC-SA 3.0 IGO.
4. Maiya AG, Gundmi S, Matpady P, Jadhav R, Lingadakai R, Hande M, Kamath VG, Shivashankar KN, Chinmayee P, Hazari A, Shastri N. Prevalence of foot complications in people with type 2 diabetes mellitus: a community-based survey in rural Udupi. Int J Low Extrem Wounds. 2018;17(3):169–75.
5. Epidemiology of diabetic foot problems. Richard JL, Schuldiner S, Rev Med I. 2008 Sep; 29Suppl 2:S222-30.
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