Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults
-
Published:2023-05-22
Issue:5
Volume:45
Page:2819-2834
-
ISSN:2509-2723
-
Container-title:GeroScience
-
language:en
-
Short-container-title:GeroScience
Author:
Chaudhari Diptaraj S., Jain Shalini, Yata Vinod K., Mishra Sidharth P., Kumar Ambuj, Fraser Amoy, Kociolek Judyta, Dangiolo Mariana, Smith Amanda, Golden Adam, Masternak Michal M., Holland Peter, Agronin Marc, White-Williams Cynthia, Arikawa Andrea Y., Labyak Corinne A., Yadav HariomORCID
Abstract
AbstractThe prevalence of age-related cognitive disorders/dementia is increasing, and effective prevention and treatment interventions are lacking due to an incomplete understanding of aging neuropathophysiology. Emerging evidence suggests that abnormalities in gut microbiome are linked with age-related cognitive decline and getting acceptance as one of the pillars of the Geroscience hypothesis. However, the potential clinical importance of gut microbiome abnormalities in predicting the risk of cognitive decline in older adults is unclear. Till now the majority of clinical studies were done using 16S rRNA sequencing which only accounts for analyzing bacterial abundance, while lacking an understanding of other crucial microbial kingdoms, such as viruses, fungi, archaea, and the functional profiling of the microbiome community. Utilizing data and samples of older adults with mild cognitive impairment (MCI; n = 23) and cognitively healthy controls (n = 25). Our whole-genome metagenomic sequencing revealed that the gut of older adults with MCI harbors a less diverse microbiome with a specific increase in total viruses and a decrease in bacterial abundance compared with controls. The virome, bacteriome, and microbial metabolic signatures were significantly distinct in subjects with MCI versus controls. Selected bacteriome signatures show high predictive potential of cognitive dysfunction than virome signatures while combining virome and metabolic signatures with bacteriome boosts the prediction power. Altogether, the results from our pilot study indicate that trans-kingdom microbiome signatures are significantly distinct in MCI gut compared with controls and may have utility for predicting the risk of developing cognitive decline and dementia- debilitating public health problems in older adults.
Funder
Florida Department of Health National Institutes of Health, NIA Peer Reviewed Alzheimer’s Research Program
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging
Reference62 articles.
1. Andrews S. FastQC: a Quality Control Tool for High Throughput Sequence Data [Online]. 2010. Available online at: http://www.bioinformatics.babraham.ac.uk/projects/fastqc/. 2. Angelucci F, Cechova K, Amlerova J, Hort J. Antibiotics, gut microbiota, and Alzheimer’s disease. J Neuroinflammation. 2019;16:1–10. 3. Arnoldussen I, Wiesmann M, Pelgrim C, Wielemaker E, Van Duyvenvoorde W, Amaral-Santos P, Verschuren L, Keijser B, Heerschap A, Kleemann R, Wielinga PY, Kiliaan AJ. Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice. Int J Obes (Lond). 2017;41:935–44. 4. Bajaj JS, Hylemon PB, Ridlon JM, Heuman DM, Daita K, White MB, Monteith P, Noble NA, Sikaroodi M, Gillevet PM. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol. 2012;303:G675–85. 5. Beghini F, McIver LJ, Blanco-Míguez A, Dubois L, Asnicar F, Maharjan S, Mailyan A, Manghi P, Scholz M, Thomas AM, et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife. 2021;10:e65088.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|