Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry
Link
http://link.springer.com/article/10.1007/s12192-018-0877-2/fulltext.html
Reference138 articles.
1. Alderson TR, Kim JH, Markley JL (2016) Dynamical structures of Hsp70 and Hsp70-Hsp40 complexes. Structure 24(7):1014–1030. https://doi.org/10.1016/j.str.2016.05.011
2. Ali A, Bharadwaj S, O'Carroll R, Ovsenek N (1998) HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes. Mol Cell Biol 18(9):4949–4960. https://doi.org/10.1128/MCB.18.9.4949
3. Allan RK, Mok D, Ward BK, Ratajczak T (2006) Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization. J Biol Chem 281(11):7161–7171. https://doi.org/10.1074/jbc.M512406200
4. Anckar J, Sistonen L (2011) Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 80(1):1089–1115. https://doi.org/10.1146/annurev-biochem-060809-095203
5. Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L (2013) Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget 4(7):1065–1074. https://doi.org/10.18632/oncotarget.1099
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