Efficacy and Safety of CMAB008 Compared with Innovator Infliximab in Patients with Moderate-to-Severe Rheumatoid Arthritis Receiving Concomitant Methotrexate: A Randomized, Double-blind, Multi-center, Phase III Non-inferiority Study
Author:
Funder
Chinese National Key Technology R&D Program
Publisher
Springer Science and Business Media LLC
Subject
Immunology and Allergy,Rheumatology
Link
https://link.springer.com/content/pdf/10.1007/s40744-023-00544-2.pdf
Reference17 articles.
1. Zeng XF, Zhu SL, Tan AC, Xie XP. Disease Burden and quality of life of rheumatoid arthritis in China: a systematic review. Chin J Evid-Based Med. 2013;13(3):300–7 (In Chinese).
2. Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021;73(7):924–39. https://doi.org/10.1002/acr.24596.
3. Di Giovine FS, Nuki G, Duff GW. Tumour necrosis factor in synovial exudates. Ann Rheum Dis. 1988;47(9):768–72. https://doi.org/10.1136/ard.47.9.768.
4. Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine. 1995;7(3):251–9. https://doi.org/10.1006/cyto.1995.0029.
5. Chu CQ, Field M, Feldmann M, Maini RN. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum. 1991;34(9):1125–32. https://doi.org/10.1002/art.1780340908.
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