Author:
Lowe Donna,Roy Laurence,Tabocchini Maria Antonella,Rühm Werner,Wakeford Richard,Woloschak Gayle E.,Laurier Dominique
Abstract
AbstractDespite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
Publisher
Springer Science and Business Media LLC
Subject
General Environmental Science,Radiation,Biophysics
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