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Risk of Adverse Cardiovascular Events Following a Myocardial Infarction in Patients Receiving Combined Clopidogrel and Proton Pump Inhibitor Treatment: A Nested Case–Control Study

  • Published:2020-07-02 Issue:3 Volume:7 Page:191-203
  • ISSN:2199-1154
  • Container-title:Drugs - Real World Outcomes
  • language:en
  • Short-container-title:Drugs - Real World Outcomes

Author:

Farhat NawalORCID,Birkett NicholasORCID,Haddad NisrineORCID,Fortin YannickORCID,Momoli Franco,Wen Shi WuORCID,Wielgosz AndreasORCID,McNair Doug S.ORCID,Mattison Donald R.ORCID,Krewski DanielORCID

Funder

Canadian Institutes of Health Research - Doctoral Award

McLaughlin Center for Population Health Risk Assessment

University of Ottawa

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical)

Reference39 articles.

1. Pelliccia F, Rollini F, Marazzi G, Greco C, Gaudio C, Angiolillo DJ. Drug–drug interactions between clopidogrel and novel cardiovascular drugs. Eur J Pharmacol. 2015;765:332–6. https://doi.org/10.1016/j.ejphar.2015.08.059 .

2. Bhatt B, Scheiman J, Abraham N, Antman E, Chan F, Furberg F, et al. ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2008;52:1502–17. https://doi.org/10.1016/j.jacc.2008.08.002 .

3. Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010;38:92–9. https://doi.org/10.1124/dmd.109.029132 .

4. Farhat N, Fortin Y, Haddad N, Birkett N, Mattison D, Momoli F, et al. Systematic review and meta-analysis of adverse cardiovascular events associated with concomitant use of proton pump inhibitors and antiplatelet agents. Crit Rev Toxicol. 2019. https://doi.org/10.1080/10408444.2019.1583167 .

5. Kim SC, Solomon DH, Rogers JR, Gale S, Klearman M, Sarsour K, et al. Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi-database cohort study. Arthritis Rheumatol. 2017;69:1154–64. https://doi.org/10.1002/art.40084 .

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