Abstract
AbstractGranulocyte colony-stimulating factor (G-CSF)-producing tumors have an aggressive clinical course. Here, we report five cases of G-CSF-producing tumors and review the literature, focusing on imaging findings related to tumor-produced G-CSF. In addition to our cases, we identified 30 previous reports of G-CSF-producing tumors on which 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT, bone scintigraphy, or evaluation of bone marrow MR findings was performed. White blood cell count, serum C-reactive protein, and serum interleukin-6 were elevated in all cases for which these parameters were measured. G-CSF-producing tumors presented large necrotic masses (mean diameter 83.2 mm, range 17–195 mm) with marked FDG uptake (mean maximum standardized uptake value: 20.09). Diffuse FDG uptake into the bone marrow was shown in 28 of the 31 cases in which FDG-PET/CT was performed. The signal intensity of bone marrow suggested marrow reconversion in all seven MRI-assessable cases. Bone scintigraphy demonstrated no significant uptake, except in two cases with bone metastases. Splenic FDG uptake was increased in 8 of 10 cases in which it was evaluated. These imaging findings may reflect the effects of tumor-produced G-CSF. The presence of G-CSF-producing tumors should be considered in patients with cancer who show these imaging findings and marked inflammatory features of unknown origin.
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging
Reference66 articles.
1. Murata Y, Kubota K, Yukihiro M, Ito K, Watanabe H, Shibuya H. Correlations between 18F-FDG uptake by bone marrow and hematological parameters: Measurements by PET/CT. Nucl Med Biol. 2006;33:999–1004. https://doi.org/10.1016/j.nucmedbio.2006.09.005.
2. Izumo W, Furukawa K, Katsuragawa H, Tezuka T, Furukawa T, Hataji K, et al. Granulocyte-colony stimulating factor-producing gallbladder carcinoma-include analysis all case reports: a case report. Int J Surg Case Rep. 2016;21:87–90. https://doi.org/10.1016/j.ijscr.2016.02.037.
3. Sakamoto Y, Kamiyama T, Yokoo H, Shimada S, Einama T, Wakayama K, et al. Hepatocellular carcinoma producing granulocyte colony-stimulating factor: diagnosis and treatment. Int Cancer Conf J. 2019;8:12–6. https://doi.org/10.1007/s13691-018-0346-x.
4. Moro K, Nagahashi M, Naito T, Nagai Y, Katada T, Minagawa M, et al. Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor: a case of a rare malignancy. Surg Case Rep. 2017;3:67. https://doi.org/10.1186/s40792-017-0338-7.
5. Mizuno M, Miyoshi T, Nabeshima K, Iwasaki A, Shirakusa T. Pleomorphic carcinoma of the lung with high serum granulocyte colony stimulating factor, suggested of pulmonary abscess by preoperative radiology; report of a case. Kyobu Geka. 2006;59:859–63 (in Japanese).
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