Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
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Published:2023-10-24
Issue:3
Volume:39
Page:919-928
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ISSN:0931-041X
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Container-title:Pediatric Nephrology
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language:en
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Short-container-title:Pediatr Nephrol
Author:
Sutherland Scott M., Alobaidi Rashid, Gorga Stephen M., Iyengar Arpana, Morgan Catherine, Heydari Emma, Arikan A. Ayse Akcan, Basu Raj K., Goldstein Stuart L., Zappitelli MichaelORCID, Askenazi David J., Bagshaw Sean M., Barhight Matthew, Barreto Erin, Bayrakci Benan, Bignall O. N. Ray, Bjornstad Erica, Brophy Patrick, Charlton Jennifer, Chanchlani Rahul, Conroy Andrea L., Deep Akash, Devarajan Prasad, Dolan Kristin, Fuhrman Dana Y., Gist Katja M., Greenberg Jason H., Hasson Denise, Jetton Jennifer, Krawczeski Catherine, Meigs Leslie, Menon Shina, Morgan Jolyn, Mottes Theresa, Neumayr Tara, Ricci Zaccaria, Selewski David T., Soranno Danielle, Stanski Natalja, Starr Michelle, Symons Jordan, Tavares Marcelo, Vega Molly, Ronco Claudio, Mehta Ravindra L., Kellum John, Ostermann Marlies,
Abstract
AbstractThe nephrology and critical care communities have seen an increase in studies exploring acute kidney injury (AKI) epidemiology in children. As a result, we now know that AKI is highly prevalent in critically ill neonates, children, and young adults. Furthermore, children who develop AKI experience greater morbidity and higher mortality. Yet knowledge gaps still exist that suggest a more comprehensive understanding of AKI will form the foundation for future efforts designed to improve outcomes. In particular, the areas of community acquired AKI, AKI in non-critically ill children, and cohorts from low-middle income countries have not been well studied. Longer-term functional outcomes and patient-centric metrics including social determinants of health, quality of life, and healthcare utilization should be the foci of the next phase of scholarship. Current definitions identify AKI-based upon evidence of dysfunction which serves as a proxy for injury; biomarkers capable of identifying injury as it occurs are likely to more accurately define populations with AKI. Despite the strength of the association, the causal and mechanistic relationships between AKI and poorer outcomes remain inadequately examined. A more robust understanding of the relationship represents a potential to identify therapeutic targets. Once established, a more comprehensive understanding of AKI epidemiology in children will allow investigation of preventive, therapeutic, and quality improvement interventions more effectively.
Publisher
Springer Science and Business Media LLC
Subject
Nephrology,Pediatrics, Perinatology and Child Health
Reference72 articles.
1. Goldstein SL, Akcan-Arikan A, Alobaidi R, Askenazi DJ, Bagshaw SM, Barhight M, Barreto E, Bayrakci B, Bignall ONR, Bjornstad E, Brophy PD, Chanchlani R, Charlton JR, Conroy AL, Deep A, Devarajan P, Dolan K, Fuhrman DY, Gist KM, Gorga SM, Greenberg JH, Hasson D, Ulrich EH, Iyengar A, Jetton JG, Krawczeski C, Meigs L, Menon S, Morgan J, Morgan CJ, Mottes T, Neumayr TM, Ricci Z, Selewski D, Soranno DE, Starr M, Stanski NL, Sutherland SM, Symons J, Tavares MS, Vega MW, Zappitelli M, Ronco C, Mehta RL, Kellum J, Ostermann M, Basu RK, for the Pediatric ADQI Collaborative (2022) Consensus-based recommendations on priority activities to address acute kidney injury in children: a modified Delphi consensus statement. JAMA Netw Open 5:e2229442 2. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212 3. Kidney Disease: Improving Global Outcomes (KDIGO) Acute kidney injury work group (2012) KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int 2:1–138 4. Jetton JG, Boohaker LJ, Sethi SK, Wazir S, Rohatgi S, Soranno DE, Chishti AS, Woroniecki R, Mammen C, Swanson JR, Sridhar S, Wong CS, Kupferman JC, Griffin RL, Askenazi DJ (2017) Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. Lancet Child Adolesc Health 1:184–194 5. Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL, AWARE Investigators (2017) Epidemiology of acute kidney injury in critically Ill children and young adults. N Engl J Med 376:11–20
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