Abstract
Abstract
Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C6 unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray diffraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC50 = 12.30–24.57 µM).
Graphical Abstract
Funder
NSFC-Joint Foundation of Yunnan Province
the Second Tibetan Plateau Scientific Expedition and Research (STEP) program
Natural Science Foundation of Yunnan
CAS Interdisciplinary Innovation Team of CAS “Light of West China” Program
State Key Laboratory of Protein and Plant Gene Research
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Plant Science,Pharmacology,Toxicology,Biochemistry,Food Science,Analytical Chemistry