Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics

Author:

Peng LiyuanORCID,Song Ziping,Zhao Chengcheng,Abuduwufuer Kudusi,Wang Yanwen,Wen Zheng,Ni Li,Li Chenze,Yu Ying,Zhu Yi,Jiang Hualiang,Shen Jinshan,Jiang Xiangrui,Chen Chen,Zhang Xu,Wang Dao Wen

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference63 articles.

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2. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y (2007) Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci USA 104(21):9018–9023. https://doi.org/10.1073/pnas.0703229104

3. Alaeddine LM, Harb F, Hamza M, Dia B, Mogharbil N, Azar NS, Noureldein MH, El Khoury M, Sabra R, Eid AA (2021) Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats. Translat Res 235:85–101. https://doi.org/10.1016/j.trsl.2021.03.010

4. Alex L, Russo I, Holoborodko V, Frangogiannis NG (2018) Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol 315(4):H934-h949. https://doi.org/10.1152/ajpheart.00238.2018

5. Askari A, Thomson SJ, Edin ML, Zeldin DC, Bishop-Bailey D (2013) Roles of the epoxygenase CYP2J2 in the endothelium. Prostaglandins Other Lipid Mediat 107:56–63. https://doi.org/10.1016/j.prostaglandins.2013.02.003

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