Abstract
AbstractDiffusion MRI tractography (dMRI) has fundamentally transformed our ability to investigate white matter pathways in the human brain. While long-range connections have extensively been studied, superficial white matter bundles (SWMBs) have remained a relatively underexplored aspect of brain connectivity. This study undertakes a comprehensive examination of SWMB connectivity in both the human and chimpanzee brains, employing a novel combination of empirical and geometric methodologies to classify SWMB morphology in an objective manner. Leveraging two anatomical atlases, the Ginkgo Chauvel chimpanzee atlas and the Ginkgo Chauvel human atlas, comprising respectively 844 and 1375 superficial bundles, this research focuses on sparse representations of the morphology of SWMBs to explore the little-understood superficial connectivity of the chimpanzee brain and facilitate a deeper understanding of the variability in shape of these bundles. While similar, already well-known in human U-shape fibers were observed in both species, other shapes with more complex geometry such as 6 and J shapes were encountered. The localisation of the different bundle morphologies, putatively reflecting the brain gyrification process, was different between humans and chimpanzees using an isomap-based shape analysis approach. Ultimately, the analysis aims to uncover both commonalities and disparities in SWMBs between chimpanzees and humans, shedding light on the evolution and organization of these crucial neural structures.
Funder
Blaise Pascal International Chair of Excellence awarded to Pr. William Hopkins from Ile-de-France region
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Publisher
Springer Science and Business Media LLC
Reference63 articles.
1. Armstrong E, Schleicher A, Omran H, Curtis M, Zilles K (1995) The ontogeny of human gyrification. Cereb Cortex 5(1):56–63
2. Autrey MM, Reamer LA, Mareno MC, Sherwood CC, Herndon JG, Preuss T, Schapiro SJ, Hopkins WD (2014) Age-related effects in the neocortical organization of chimpanzees: Gray and white matter volume, cortical thickness, and gyrification. Neuroimage 101:59–67
3. Avants BB, Tustison N, Song G et al (2009) Advanced normalization tools (ants). Insight j 2(365):1–35
4. Bellekens B, Spruyt V, Berkvens R, Weyn M (2014) A survey of rigid 3d pointcloud registration algorithms. AMBIENT 2014: the Fourth International Conference on Ambient Computing, Applications, Services and Technologies, August 24-28, 2014, Rome, Italy, 8–13
5. Bryant KL, Li L, Eichert N, Mars RB (2020) A comprehensive atlas of white matter tracts in the chimpanzee. PLoS Biol 18(12):e3000971