Sucralfate in Nonulcer Dyspepsia, Gastritis, and Duodenitis

Author:

Guslandi M.

Publisher

Springer US

Reference9 articles.

1. Kairaluoma M, Hentilae R, Alavaikko M, et al: Sucralfate versus placebo in the treatment of nonulcer dyspepsia. Am J Med 83(suppl 3B):51–55, 1987. A major study on the use of sucralfate in dyspeptic patients with either organic or functional forms of dyspepsia.

2. Barbara L, Biasco G, Capurso L, et al: Effects of sucralfate and sulglycotide treatment on active gastritis and Helicobacter pylori colonization of the gastric mucosa in non-ulcer dyspepsia patients. Am J Gastroenterol 85:1109–1113, 1990. An important study on the effects of sucralfate on histological gastritis and on the (lack of) relation to H. pylori infection.

3. Psilogenis M, Nazzari M, Ferrari PA: A multicenter double-blind study of sulglycotide versus sucralfate in nonulcer dyspepsia. Int J Clin Pharmacol Ther Toxicol 28:369–374, 1990. Possibly the only published study where the efficacy of sucralfate in nonulcer dyspepsia has been compared with that of an active drug.

4. Skoubo-Kristensen E, Funch-Jensen P, Kruse A, et al Controlled clinical trial with sucralfate in the treatment of macroscopic gastritis. Scand J Gastroenterol 24:716–720, 1989. The only example of negative results of sucralfate in the treatment of gastritis. A matter of type-2 error?

5. Guslandi M: Comparison of sucralfate and ranitidine in the treatment of chronic nonerosive gastritis. A randomized, multicenter trial. Am J Med 86(suppl 6A):45–48, 1989. The largest trial on the treatment of gastritis with sucralfate and the only one directly comparing the drug with an H2-receptor antagonist as regards clinical, endoscopic, and histological results.

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