Computational screening of phytocompound isolated from the plant Toddalia asiatica and Coleonema album as potential inhibitors against enzyme DPP-4 as a treatment for Type-2 Diabetes mellitus

Author:

Upendra Raje SiddirajuORCID,Srinivas Nagar Sanjay,Vasudevan Karthick

Publisher

Springer Science and Business Media LLC

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,General Chemical Engineering,Biochemistry,General Chemistry

Reference25 articles.

1. Alagaraj P, Muthukrishnan S (2020) Toddalia asiatica L.-A rich source of phytoconstituents with potential pharmacological actions, an appropriate plant for recent global arena. Cardiovasc Hematol Agents Med Chem (formerly Cardiovasc Hematol Agents Med Chem) 18(2):104–110. https://doi.org/10.2174/1871525718666200212095756

2. Ambhore JP, Laddha PR, Nandedkar A, Ajmire PV, Chumbhale DS, Navghare AB, Adhao VS (2023) Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 Diabetes mellitus: Insights on recent development. J Mol Struct 1284:135249. https://doi.org/10.1016/j.molstruc.2023.135249

3. Anirudh Sreenivas BK, Akshaya B, Ravi L, Krishnan K (2022) Protocols for preclinical evaluation and molecular docking of antimicrobial compounds from Streptomyces sp., drug likeliness evaluation, adme-toxicity investigation, docking modes between the ligand and the target enzyme, and active site prediction. Methods Actinobacteriol. https://doi.org/10.1007/978-1-0716-1728-1_37

4. Bindu B, Vijayalakshmi S, Manikandan A (2020) Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities. Eur J Med Chem 187:111912. https://doi.org/10.1016/j.ejmech.2019.111912

5. Chandrasekaran S, de Mejia EG (2022) Optimization, identification, and comparison of peptides from germinated chickpea (Cicer arietinum) protein hydrolysates using either papain or ficin and their relationship with markers of type 2 diabetes. Food Chem 374:131717. https://doi.org/10.1016/j.foodchem.2021.131717

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