CDK4/6 Inhibition in the Metastatic Setting: Where Are We Headed?

Author:

Sakach ElizabethORCID,Keskinkilic Merve,Wood Sarah,Canning Madison,Kalinsky Kevin

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference62 articles.

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2. •• Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Hart L, et al. Overall survival with ribociclib plus letrozole in advanced breast cancer. N Engl J Med. 2022;386(10):942–50. Final OS analysis of the randomized, double-blind, placebo-controlled, phase III MONALEESA-2 trial with ribociclib plus letrozole demonstrating OS benefit in the front line.

3. Neven PFP, Chia S, Jerusalem G, Im S, Petrakova K, Bianchi G, Martin Jimenez M, Nusch A, Sonke GS, de la Cruz merino L, Zarate JP, Wang Y, Chakravatty A, Wang C, Slamon D. editor Updated overall survival (OS) results from the first-line population in the phase III MONALEESA-3 trial of postmenopausal patients with HR+HER2- advanced breast cancer treated with ribociclib + fulvestrant. ESMO Breast Cancer Congres; 2022.

4. •• M.P. Goetz MT, J. Huober, J. Sohn, O. Tredan, I.H. Park, M. Campone, S.C. Chen, L.M. Manso Sanchez, S. Paluch-Shimon, G. van Hal, A. Shahir, H. Iwata, S. Johnston, editor MONARCH 3: interim overall survival (OS) results of abemaciclib plus a nonsteroidal aromatase inhibitor (NSAI) in patients (pts) with HR+, HER2- advanced breast cancer (ABC). ESMO Congress; 2022. Second interim OS analysis from the randomized, double-blind, placebo-controlled, phase III MONARCH-3 trial with abemaciclib plus AI demonstrating OS benefit in front line.

5. •• Lu Y-S, Im S-A, Colleoni M, Franke F, Bardia A, Cardoso F, et al. Updated overall survival of ribociclib plus endocrine therapy versus endocrine therapy alone in pre- and perimenopausal patients with HR+/HER2− advanced breast cancer in MONALEESA-7: a phase III randomized clinical trial. Clin Cancer Res. 2022;28(5):851–9. (Exploratory OS analysis with extended follow-up (median 53.5 months) for the randomized, double-blind, placebo-controlled, phase III MONALEESA-7 trial showing consistent OS benefit with ribociclib plus ET in peri/premenopausal patients in the front line.)

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