Author:
Yu Lanying,Liu Tiantian,Fu Shuang,Li Li,Meng Xiaoping,Su Xin,Xie Zhanfeng,Ren Jiayan,Meng Yan,Lv Xuejiao,Du Yanwei
Abstract
AbstractUrea transporters (UTs) are membrane proteins in the urea transporter protein A (UT-A) and urea transporter protein B (UT-B) families. UT-B is mainly expressed in endothelial cell membrane of the renal medulla and in other tissues, including the brain, heart, pancreas, colon, bladder, bone marrow, and cochlea. UT-B is responsible for the maintenance of urea concentration, male reproductive function, blood pressure, bone metabolism, and brain astrocyte and cardiac functions. Its deficiency and dysfunction contribute to the pathogenesis of many diseases. Actually, UT-B deficiency increases the sensitivity of bladder epithelial cells to apoptosis triggers in mice and UT-B-null mice develop II-III atrioventricular block and depression. The expression of UT-B in the rumen of cow and sheep may participate in digestive function. However, there is no systemic review to discuss the UT-B functions. Here, we update research approaches to understanding the functions of UT-B.
Funder
National Natural Science Foundation of China
Excellent Youth Fund of Jilin Provincial Science and Technology Department
National College Students' innovation and entrepreneurship training program
College project grants
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Clinical Biochemistry,Physiology
Cited by
17 articles.
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