CFTR—a (novel) target in ARDS

Author:

Frick Manfred

Funder

Universität Ulm

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Clinical Biochemistry,Physiology

Reference12 articles.

1. Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ (1991) Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253:202–205. https://doi.org/10.1126/science.1712984

2. Bombieri C, Seia M, Castellani C (2015) Genotypes and phenotypes in cystic fibrosis and cystic fibrosis transmembrane regulator-related disorders. Semin Respir Crit Care Med 36:180–193. https://doi.org/10.1055/s-0035-1547318

3. Csanady L, Torocsik B (2019) Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations. Elife 8:e46450. https://doi.org/10.7554/eLife.46450

4. Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM (2022) Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med 14:eabg8577. https://doi.org/10.1126/scitranslmed.abg8577

5. Honrubia JM, Gutierrez-Alvarez J, Sanz-Bravo A, Gonzalez-Miranda E, Munoz-Santos D, Castano-Rodriguez C, Wang L, Villarejo-Torres M, Ripoll-Gomez J, Esteban A, Fernandez-Delgado R, Sanchez-Cordon PJ, Oliveros JC, Perlman S, McCray PB Jr., Sola I, Enjuanes L (2023) SARS-CoV-2-mediated lung edema and replication are diminished by cystic fibrosis transmembrane conductance regulator modulators. mBio:e0313622. https://doi.org/10.1128/mbio.03136-22

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