A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells

Author:

Kawano Takeshi,Agata Naoki,Kharbanda Surender,Avigan David,Kufe Donald

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference17 articles.

1. Soulie P, Gamelin E, Eder J (2003) A dose finding study of an oral antiangiogenesis inhibitor, NM-3 safety profile and effects on surrogate markers with once-daily dosing. Abstract No. 777. Proc Amer Soc Clin Oncol

2. Bonate P, Eder J, Soulie P (2003) Pharmacokinetics of a new antiangiogenic isocoumarin derivative, NM-3 in two oral once a day-dose schedules with escalating doses, Abstract No. 537. Proc Amer Soc Clin Oncol 22:132

3. Nakashima T, Hirano S, Agata N et al (1999) Inhibition of angiogenesis by a new isocoumarin, NM-3. J Antibiot 52:426–428

4. Salloum R, Jaskowiak N, Mauceri H et al (2000) NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res 60:6958–6963

5. Agata N, Tsuchiya A, Issihiki K (2001) NM-3, a novel orally bioavilable antiangeiogenic agents suppresses hypoxia-induced vascular endothelial growth factor (VEGF) in human fibroblasts and tumor cells. Proc AACR 41:587

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