Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells

Author:

Hamed Salaheldin S.,Straubinger Robert M.,Jusko William J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference42 articles.

1. Hui YF, Reitz J (1997) Gemcitabine: a cytidine analogue active against solid tumors. Am J Health Syst Pharm 54:162–170

2. Hilbig A, Oettle H (2008) Gemcitabine in the treatment of metastatic pancreatic cancer. Expert Rev Anticancer Ther 8:511–523

3. Heinemann V, Hertel LV, Grindey GB, Plunkett W (1988) Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-b-arabinofuranosylcytosine. Cancer Res 48:4024–4031

4. Carpenelli G, Bucci G, D’Agnano I, Canese R, Caroli F, Raus L, Brunetti E, Giannarelli E, Podo F, Carapella CM (2006) Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate. Anticancer Res 26:3017–3024

5. Cappella P, Tomasoni D, Faretta M, Lupi M, Montalenti F, Viale F, Banzato F, D’Incalci M, Ubezio P (2001) Cell cycle effects of gemcitabine. Int J Cancer 93:401–408

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