Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation-Reference-Cited by-同舟云学术

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

Published:1977-12 Issue:6 Volume:5 Page:655-680
ISSN:0090-466X
Container-title:Journal of Pharmacokinetics and Biopharmaceutics
language:en
Short-container-title:Journal of Pharmacokinetics and Biopharmaceutics

Author:

Pang K. Sandy,Rowland Malcolm

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/BF01059689.pdf

Reference28 articles.

1. K. S. Pang and M. Rowland. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.J. Pharmokin. Biopharm. 5:625–653 (1977).

2. M. Rowland, L. Z. Benet, and G. E. Graham. Clearance concepts in pharmacokinetics.J. Pharmacokin. Biopharm. 1:123–136 (1973).

3. K. Winkler, S. Keiding, and N. Tygstrup. Clearance as a quantitative measure of liver function. In P. Paumgartner and R. Presig (eds.),The Liver: Quantitative Aspects of Structure and Function, Karger, Basel, 1973, pp. 144–155.

4. K. Winkler, L. Bass, S. Keiding, and N. Tygstrup. The effect of hepatic perfusion on the assessment of kinetic constants. In F. Lundquist and N. Tygstrup (eds.),Alfred Benzon Symposium VI: The Regulation of Hepatic Metabolism, Munksgaard, Copenhagen, 1974. pp. 797–807.

5. G. E. Mortimore. Effect of insulin on potassium transfer in isolated rat liver.Am. J. Physiol. 200:1315–1319 (1961).

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