Hyperinsulinemia: a Cause of Obesity?

Author:

Erion Karel A.,Corkey Barbara E.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference100 articles.

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2. •• Schlogl M, Piaggi P, Pannacciuli N, Bonfiglio SM, Krakoff J, Thearle MS. Energy expenditure responses to fasting and overfeeding identify phenotypes associated with weight change. Diabetes. 2015;64(11):3680–9. A decrease in 24-h energy expenditure during fasting and an increase with overfeeding correlated with a larger reduction in weight gain during fasting; a smaller response to low-protein overfeeding and a larger response to high-carbohydrate overfeeding correlated with weight gain

3. •• Fothergill E, Guo J, Howard L, Kerns JC, Knuth ND, Brychta R, et al. Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity (Silver Spring). 2016;24(8):1612–9. doi: 10.1002/oby.21538 . Fourteen of the 16 “Biggest Loser” competitors participated in a follow-up study. Weight loss at the end of the competition averaged 58.3, and RMR decreased by 610 kcal/day. After 6 years, 41.0 kg of the lost weight was regained, while RMR was 704 kcal/day below baseline and metabolic adaptation was −499 kcal/day

4. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J. Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes. 1995;44(9):1121–5.

5. Moro E, Gallina P, Pais M, Cazzolato G, Alessandrini P, Bittolo-Bon G. Hypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance: evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes. Metabolism. 2003;52(5):616–9. doi: 10.1053/meta.2003.50102 .

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