Glycyrrhizic Acid Reverses Neurological Deficits by Attenuating Rac1-STAT3 Signalling-Mediated Neuroinflammation in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy

Author:

Guo YijingORCID,Wu ShanshanORCID,Le KaiORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference60 articles.

1. Ahmed HA, Ishrat T, Pillai B, Fouda AY, Sayed MA, Eldahshan W, Waller JL, Ergul A, Fagan SC (2018) RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation 15:229. https://doi.org/10.1186/s12974-018-1262-x

2. Akutagawa K, Fujita T, Ouhara K, Takemura T, Tari M, Kajiya M, Matsuda S, Kuramitsu S, Mizuno N, Shiba H, Kurihara H (2019) Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice. Int Immunopharmacol 68:30–38. https://doi.org/10.1016/j.intimp.2018.12.045

3. Bartha AI, Foster-Barber A, Miller SP, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM (2004) Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome. Pediatr Res 56:960–966. https://doi.org/10.1203/01.PDR.0000144819.45689.BB

4. Bassi R, Giussani P, Anelli V, Colleoni T, Pedrazzi M, Patrone M, Viani P, Sparatore B, Melloni E, Riboni L (2008) HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration. J Neuro-Oncol 87:23–33. https://doi.org/10.1007/s11060-007-9488-y

5. Chen H et al (2020) Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis through targeting peroxynitrite-mediated HMGB1 signaling. Transl Stroke Res 11:967–982. https://doi.org/10.1007/s12975-019-00772-1

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