Author:
Li Jiajing,Zhang Hongfei,Du Qian,Gu Junyu,Wu Jiangbo,Liu Qi,Li Zhuo,Zhang Ting,Xu Jingyu,Xie Rui
Abstract
AbstractFor a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various diseases. Our group has been engaged in the study of ion channels. In recent years, the report rate of TRPA1, the only member of the TRPA subfamily in the newly described TRP channel, has been very high. TRPA1 channels are not only abundantly expressed in peptidergic nociceptors but are also found in many nonneuronal cell types and tissues, and through the regulation of Ca2+ influx, various neuropeptides and signaling pathways are involved in the regulation of nerves, respiration, circulation, and various diseases and inflammation throughout the body. In this review, we mainly summarize the effects of TRPA1 on various systems in the body, which not only allows us to have a more systematic and comprehensive understanding of TRPA1 but also facilitates more in-depth research on it in the future.
Graphical Abstract
Funder
National Natural Science Foundation of China
Guizhou Provincial Department of Science and Technology Excellent Youth Project
Collaborative Innovation Center of Chinese Ministry of Education
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology,Biophysics
Reference143 articles.
1. Adhya P, Sharma SS (2019) Redox TRPs in diabetes and diabetic complications: mechanisms and pharmacological modulation. Pharmacol Res 146:104271
2. Ahmed B, Qadir MI, Ghafoor S (2020) Malignant melanoma: skin cancer-diagnosis, prevention, and treatment. Crit Rev Eukaryot Gene Expr 30:291–297
3. Andersson KE (2019) Agents in early development for treatment of bladder dysfunction—promise of drugs acting at TRP channels? Expert Opin Investig Drugs 28:749–755
4. Andrade EL, Forner S, Bento AF, Leite DF, Dias MA, Leal PC, Koepp J, Calixto JB (2011) TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Am J Physiol Renal Physiol 300:F1223-1234
5. Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M et al (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118:2574–2582
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献