Author:
Silbert Richard,Salcido-Montenegro Alejandro,Rodriguez-Gutierrez Rene,Katabi Abdulrahman,McCoy Rozalina G.
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
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. This post hoc analysis of the ADVANCE trial examined the patient- and treatment-specific risk factors for hypoglycemia. Furthermore, this study found that severe hypoglycemia, irrespective of the study arm, significantly increased the risks of all-cause mortality (HR 2.69; 95% CI, 1.97–3.67), cardiovascular mortality (HR 2.68; 95% CI, 1.72–4.19), major macrovascular events (HR 2.88; 95% CI, 2.01–4.12), and major microvascular events (HR 1.81; 95% CI, 1.19–2.74).
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