Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads Using Box–Behnken Design and Desirability Function for Colon Targeting

Author:

Pandey Amit Kumar,Sara Udaivir Singh

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science

Reference24 articles.

1. Ramanathan, Ramesh K, Clark, Jeffery W. Safety and toxicity analysis of oxaliplatin combined with fluorouracil or as a single agent in patients with previously treated advanced colorectal cancer. Am Soc Clin Oncol. 2003;2904–11.

2. Dhawale SC, Bankar AS, Patro MN. Formulation and evaluation of porous microspheres of 5-fluorouracil for colon targeting. Int J Pharmtech Res. 2010;1112–18.

3. Wong HL, Bendayan R, Rauth AM. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007;59:491–504.

4. Michor F, Iwasa Y, Lengauer C, Nowak NA. Dynamics of colorectal cancer. Semin Cancer Biol. 2013;15:484–93.

5. Mohideen B, Ezhilmuthu RP, et al. Formulation and in vitro characterization of gliclazide-loaded polymeric nanoparticles. Int J Biol Pharm Res. 2005;4(7):533–40.

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