Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model

Author:

Jahn Ashley,Bodreau Charlie,Farthing Kate,Elbarbry FawzyORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference22 articles.

1. Davies M. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci. 2003;28(4):263–74.

2. Health Legacy. Alcohol Withdrawal Protocol. 2015;900(6509):1–17.

3. Food and Drug Administration. Select Committee on GRAS Substances (SCOGS) Opinion: Propylene Glycol and Propylene Glycol Monostearate (September 2015). https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070347.pdf . Accessed May 2015.

4. Food and Drug Administration. Generally Recognized as Safe (GRAS) (February 2017). https://www.fda.gov/food/guidanceregulation/guidancedocumentsregulatoryinformation/ingredientsadditivesgraspackaging/default.htm#GRAS . Accessed May 2017.

5. Wilson KC, Reardon C, Theodore AC, Farber HW. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Chest. 2005;128(3):1674–81.

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