Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
http://link.springer.com/content/pdf/10.1007/s12079-009-0043-9.pdf
Reference130 articles.
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2. Abreu JG, Ketpura NI, Reversade B, De Robertis EM (2002) Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 4:599–604
3. Adler SG, Schwartz SM, Williams ME, Arauz-Pacheco C, Bolton WK, Lee TH, Coker G, Sewell KL (2006) Dose-escalation phase I study of FG-3019, anti-CTGF monoclonal antibody, in patients with type 1/2 diabetes mellitus and microalbuminuria. J Am Soc Nephrol 17:157A. doi: 10.1681/ASN.2006111191
4. Aikawa T, Gunn J, Spong SM, Klaus SJ, Korc M (2006) Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 5:1108–1116. doi: 10.1158/1535-7163.MCT-05-0516
5. Aoki Y, Maeno T, Aoyagi K, Ueno M, Aoki F, Aoki N, Nakagawa J, Sando Y, Shimizu Y, Suga T, Arai M, Kurabayashi M (2008) Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis. Respiration. doi: 10.1159/000168676
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