Author:
Wang Youmeng,Schoebel Juliane,Han Jinming,Kraemer Jan F.,Toncar Theresa,Siegert Jacob,Penzel Thomas,Schöbel Christoph
Abstract
Abstract
Objective
Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF.
Methods
This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography.
Results
A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea–hypopnea index (41 ± 18 vs 29 ± 25, p = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% ± 1% vs 95% ± 2%, p = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea.
Conclusion
In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF.
Funder
Charité - Universitätsmedizin Berlin
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Otorhinolaryngology
Cited by
1 articles.
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