The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex
Author:
Funder
National Institute of Neurological Disorders and Stroke
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00401-023-02621-w.pdf
Reference19 articles.
1. Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G et al (2021) Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta Neuropathol 141:159–172. https://doi.org/10.1007/s00401-020-02255-2
2. Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J et al (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 117:613–634. https://doi.org/10.1007/s00401-009-0538-8
3. Bhatia TN, Clark RN, Needham PG, Miner KM, Jamenis AS, Eckhoff EA et al (2021) Heat shock protein 70 as a sex-skewed regulator of alpha-synucleinopathy. Neurotherapeutics 18:2541–2564. https://doi.org/10.1007/s13311-021-01114-6
4. Bhatia TN, Jamenis AS, Abbas M, Clark RN, Miner KM, Chandwani MN et al (2023) A 14-day pulse of PLX5622 modifies alpha-synucleinopathy in preformed fibril-infused aged mice of both sexes. Neurobiol Dis. https://doi.org/10.1016/j.nbd.2023.106196
5. Borghammer P, Just MK, Horsager J, Skjaerbaek C, Raunio A, Kok EH et al (2022) A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease. NPJ Parkinsons Dis 8:166. https://doi.org/10.1038/s41531-022-00436-2
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