Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience-Reference-Cited by-同舟云学术

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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Published:2018-07-02 Issue:2 Volume:136 Page:181-210
ISSN:0001-6322
Container-title:Acta Neuropathologica
language:en
Short-container-title:Acta Neuropathol

Author:

Capper David,Stichel Damian,Sahm Felix,Jones David T. W.,Schrimpf Daniel,Sill Martin,Schmid Simone,Hovestadt Volker,Reuss David E.,Koelsche Christian,Reinhardt Annekathrin,Wefers Annika K.,Huang Kristin,Sievers Philipp,Ebrahimi Azadeh,Schöler Anne,Teichmann Daniel,Koch Arend,Hänggi Daniel,Unterberg Andreas,Platten Michael,Wick Wolfgang,Witt Olaf,Milde Till,Korshunov Andrey,Pfister Stefan M.,von Deimling Andreas

Funder

DKFZ-HIPO_036

German Childhood Cancer Foundation

Illumina Medical Research Grant

DKTK joint funding project ‘Next Generation Molecular Diagnostics of Malignant Gliomas’

A Kids’ Brain Tumour Cure (PLGA) Foundation

Brain Tumour Charity

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine

Link

http://link.springer.com/article/10.1007/s00401-018-1879-y/fulltext.html

Reference56 articles.

1. Bady P, Delorenzi M, Hegi ME (2016) Sensitivity analysis of the MGMT-STP27 model and impact of genetic and epigenetic context to predict the MGMT methylation status in gliomas and other tumors. J Mol Diagn 18:350–361

2. Bady P, Sciuscio D, Diserens AC et al (2012) MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status. Acta Neuropathol 124:547–560

3. Brastianos PK, Taylor-Weiner A, Manley PE et al (2014) Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 46:161–165

4. Cancer Genome Atlas Research N, Brat DJ, Verhaak RG et al (2015) Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med 372:2481–2498

5. Capper D, Engel NW, Stichel D et al (2018) DNA methylation-based reclassification of olfactory neuroblastoma. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1854-7

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