Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III)
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Published:2023-05-23
Issue:10
Volume:32
Page:2951-2964
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ISSN:0962-9343
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Container-title:Quality of Life Research
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language:en
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Short-container-title:Qual Life Res
Author:
Olsen Bjorn ChristianORCID, Opheim Randi, Kristensen Vendel A., Høivik Marte Lie, Lund Charlotte, Aabrekk Tone Bergene, Johansen Ingunn, Holten Kristina, Strande Vibeke, Bengtson May-Bente, Ricanek Petr, Detlie Trond Espen, Bernklev Tomm, Jelsness-Jørgensen Lars-Petter, Huppertz-Hauss Gert
Abstract
Abstract
Purpose
This unselected, population-based cohort study aimed to determine the level of health-related quality of life (HRQoL) in patients with Crohn’s disease (CD) and ulcerative colitis (UC) at the time of diagnosis compared with a reference population and identify the demographic factors, psychosocial measures, and disease activity markers associated with HRQoL.
Methods
Adult patients newly diagnosed with CD or UC were prospectively enrolled. HRQoL was measured using the Short Form 36 (SF-36) and Norwegian Inflammatory Bowel Disease Questionnaires. Clinical significance was assessed using Cohen’s d effect size and further compared with a Norwegian reference population. Associations between HRQoL and symptom scores, demographic factors, psychosocial measures, and disease activity markers were analyzed.
Results
Compared with the Norwegian reference population, patients with CD and UC reported significantly lower scores in all SF-36 dimensions, except for physical functioning. Cohen’s d effect sizes for men and women in all SF-36 dimensions were at least moderate, except for bodily pain and emotional role for men with UC and physical functioning for both sexes and diagnoses. In the multivariate regression analysis, depression subscale scores ≥ 8 on the Hospital Anxiety and Depression Scale, substantial fatigue, and high symptom scores were associated with reduced HRQoL.
Conclusion
Patients newly diagnosed with CD and UC reported statistically and clinically significantly lower scores in seven of the eight SF-36 dimensions than the reference population. Symptoms of depression, fatigue, and elevated symptom scores were associated with poorer HRQoL.
Funder
Takeda Pharmaceuticals International Pfizer Pharmaceuticals Ferring Pharmaceuticals Tillotts Pharma EkstraStiftelsen Helse og Rehabilitering Helse Sør-Øst RHF Telemark Hospital Trust
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health
Reference40 articles.
1. Hoivik, M. L., Moum, B., Solberg, I. C., Cvancarova, M., Hoie, O., Vatn, M. H., Bernklev, T., IBSEN Study Group. (2012). Health-related quality of life in patients with ulcerative colitis after a 10-year disease course: results from the IBSEN study. Inflammatory Bowel Diseases, 18(8), 1540–1549. https://doi.org/10.1002/ibd.21863 2. Knowles, S. R., Graff, L. A., Wilding, H., Hewitt, C., Keefer, L., & Mikocka-Walus, A. (2018). Quality of life in inflammatory bowel disease: A systematic review and meta-analyses-part I. Inflammatory Bowel Diseases, 24(4), 742–751. https://doi.org/10.1093/ibd/izx100 3. Turner, D., Ricciuto, A., Lewis, A., D’Amico, F., Dhaliwal, J., Griffiths, A. M., Bettenworth, D., Sandborn, W. J., Sands, B. E., Reinisch, W., Schölmerich, J., Bemelman, W., Danese, S., Mary, J. Y., Rubin, D., Colombel, J.-F., Peyrin-Biroulet, L., Dotan, I., Abreu, M. T., International Organization for the Study of IBD. (2021). STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): Determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology, 160(5), 1570–1583. https://doi.org/10.1053/j.gastro.2020.12.031 4. Knowles, S. R., Graff, L. A., Wilding, H., Hewitt, C., Keefer, L., & Mikocka-Walus, A. (2018). Quality of life in inflammatory bowel disease: A systematic review and meta-analyses—Part II. Inflammatory Bowel Diseases, 24(5), 966–976. https://doi.org/10.1093/ibd/izy015 5. Burisch, J., Weimers, P., Pedersen, N., Cukovic-Cavka, S., Vucelic, B., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J. F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K. R., EpiCom-group. (2014). Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with inflammatory bowel disease—An ECCO-EpiCom study. Journal of Crohn’s & Colitis, 8(9), 1030–1042. https://doi.org/10.1016/j.crohns.2014.01.028
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