Preliminary Findings on Proline-Rich Protein 14 as a Diagnostic Biomarker for Parkinson’s Disease
-
Published:2020-10-01
Issue:2
Volume:23
Page:285-291
-
ISSN:1535-1084
-
Container-title:NeuroMolecular Medicine
-
language:en
-
Short-container-title:Neuromol Med
Author:
Jin Tao, Tan Xuling, Shi Xiaoliu, Lv Lingling, Peng Xinke, Zhang Hainan, Tang Beisha, Wang Chunyu, Yang MeiORCID
Abstract
AbstractThe nuclear envelope component proline-rich protein 14 (PRR14) is involved in the nuclear morphological alteration and activation of the mTOR (mammalian target of rapamycin) signaling pathway, and has been repeatedly shown to be upregulated in patients with Parkinson’s disease (PD). The aim of this study was to explore whether PRR14 can be used as a potential biomarker for the diagnosis of PD. We compared PRR14 expression in PD patients and normal controls in gene expression omnibus (GEO) data. Quantitative enzyme-linked immunosorbent assay (ELISA) was used to detect PRR14 expression in PD patients and age- and sex-matched controls. The relationship between serum PRR14 and clinical phenotype was evaluated using correlation analysis and logistic regression. The expression of PRR14 in whole blood, substantia nigra, and medial substantia nigra was significantly higher in PD patients than in the healthy control group. Compared to plasma, serum was more suitable for the detection of PRR14. Furthermore, serum PRR14 level in PD patients was significantly higher than that in age- and sex-matched controls. The area under the curve for serum PRR14 level in the ability to identify PD versus age- and sex-matched controls was 0.786. In addition, serum PRR14 level was found to correlate with constipation in PD patients. Our findings demonstrate for the first time that serum PRR14 is a potential biomarker for PD.
Funder
Young Scientists Fund
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology,Molecular Medicine
Reference37 articles.
1. Abbott, R. D., Petrovitch, H., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., et al. (2001). Frequency of bowel movements and the future risk of Parkinson's disease. Neurology, 57(3), 456–462. 2. Ascherio, A., & Schwarzschild, M. A. (2016). The epidemiology of Parkinson's disease: Risk factors and prevention. Lancet Neurology, 15(12), 1257–1272. 3. Braak, H., Vos, R. A. I. D., Bohl, J., & Tredici, K. D. (2006). Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neuroscience Letters, 396(1), 67–72. 4. Chen, W., Kang, W. Y., Chen, S., Wang, Y., Xiao, Q., Wang, G., et al. (2015). Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease. Parkinsonism & Related Disorders, 21(6), 610–614. 5. Clairembault, T., Leclair-Visonneau, L., Coron, E., Bourreille, A., Dily, S. L., Vavasseur, F., et al. (2015). Structural alterations of the intestinal epithelial barrier in Parkinson’s disease. Acta Neuropathologica Communications, 3(1), 12.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|