Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose-Reference-Cited by-同舟云学术

Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose

Published:2023-04-05 Issue:3 Volume:25 Page:415-425
ISSN:1535-1084
Container-title:NeuroMolecular Medicine
language:en
Short-container-title:Neuromol Med

Author:

Chen Pinzhong^ORCID,Chen Xiaohui^ORCID,Zhang Honghong^ORCID,Chen Jianghu^ORCID,Lin Mingxue^ORCID,Qian Haitao^ORCID,Gao Fei^ORCID,Chen Yisheng^ORCID,Gong Cansheng^ORCID,Zheng Xiaochun^ORCID,Zheng Ting^ORCID

Funder

Start up Fund for Scientific Research, Fujian Medical University

This research was supported by the National Natural Science Foundation of China

the Joint Funds for the Innovation of Science and Technology, Fujian Province

the Natural Science Foundation of Fujian Province

Provincial special subsidy funds for health care of Fujian Provincial Department of Finance

Fujian Undergraduate Education and Teaching Reform Research Major Project

Education and Teaching Reform Research Project of Fujian Medical University

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Molecular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s12017-023-08745-2.pdf

Reference43 articles.

1. Alvarez-Almazan, S., Filisola-Villasenor, J. G., Aleman-Gonzalez-Duhart, D., Tamay-Cach, F., & Mendieta-Wejebe, J. E. (2020). Current molecular aspects in the development and treatment of diabetes [J]. Journal of Physiology and Biochemistry, 76(1), 13–35. https://doi.org/10.1007/s13105-019-00717-0

2. Arrozi, A. P., Shukri, S. N. S., Ngah, W. Z. W., Yusof, Y. A. M., & Makpol, S. J. S. R. (2020). Comparative effects of alpha- and gamma-tocopherol on mitochondrial functions in Alzheimer’s disease in vitro model [J]. Scientific Reports, 10(1), 8962. https://doi.org/10.1038/s41598-020-65570-4

3. Cai, Z. Y., Yang, B., Shi, Y. X., Zhang, W. L., Liu, F., Zhao, W., & Yang, M. W. (2018). High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway [J]. Biochemical and Biophysical Research Communications, 503(2), 428–435. https://doi.org/10.1016/j.bbrc.2018.04.052

4. Chandrasekaran, K., Choi, J., Arvas, M. I., Salimian, M., Singh, S., Xu, S., Gullapalli, R. P., Kristian, T., & Russell, J. W. (2020). Nicotinamide mononucleotide administration prevents experimental diabetes-induced cognitive impairment and loss of hippocampal neurons [J]. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21113756

5. Chen, H., Ji, Y., Yan, X., Su, G., Chen, L., & Xiao, J. (2018). Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling [J]. Biomedicine & Pharmacotherapy, 108, 1201–1207. https://doi.org/10.1016/j.biopha.2018.09.140