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Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study

  • Published:2022-06-25 Issue:9 Volume:61 Page:1237-1249
  • ISSN:0312-5963
  • Container-title:Clinical Pharmacokinetics
  • language:en
  • Short-container-title:Clin Pharmacokinet

Author:

Chen Ping,Reed Greg,Jiang Joyce,Wang Yaohui,Sunega Jean,Dong Ruochen,Ma Yan,Esparham Anna,Ferrell Ryan,Levine Mark,Drisko JeanneORCID,Chen Qi

Funder

Thomas Jefferson University

School of Medicine, University of Kansas

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference37 articles.

1. Drisko JA. Chapter 8 Orthomolecular approaches for the use of intravenous vitamin C. In Vissers M, Chen Q (editors) Cancer and vitamin C: a new Odyssey for an old vitamin—biochemistry and function, vol II. pp 153–165. New York: CRC Press; 2020. https://doi.org/10.1201/9781003017493-8

2. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A. 1996;93(8):3704–9. https://doi.org/10.1073/pnas.93.8.3704.

3. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med. 2004;140(7):533–7. https://doi.org/10.7326/0003-4819-140-7-200404060-00010.

4. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005;102(38):13604–9. https://doi.org/10.1073/pnas.0506390102.

5. Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007;104(21):8749–54. https://doi.org/10.1073/pnas.0702854104.
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