Clinical applicability of current pharmacokinetic models: Splanchnic elimination of 5-fluorouracil in cancer patients

Author:

Robinson Peter J.,Bass Ludvik,Pond Susan M.,Roberts Michael S.,Wagner John G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Reference25 articles.

1. J. L. Speyer, P. H. Sugarbaker, J. M. Collins, R. L. Dedrick, R. W. Klecker, Jr., and C. E. Myers. Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans.Cancer Res. 41:1916–1922 (1981).

2. M. Chadwick and J. Rogers. The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.Cancer Res. 32:1045–1056 (1972).

3. B. G. Gustavsson, A. Brandberg, C. G. Regardh, and O. E. Almersjo. Regional and systemic serum concentration of 5-fluorouracil after portal and intravenous infusion: an experimental study in dogs.J. Pharmacokin. Biopharm. 7:665–673 (1979).

4. Y.-H. Kao, C.-Y. Yang, R. R. L. Chen, and J.-D. Huang. Pulmonary elimination of 5-fluorouracil in anesthetized rats.J. Pharm. Sci. 74:1095–1096 (1985).

5. J. G. Wagner, J. W. Gyves, P. L. Stetson, S. C. Walker-Andrews, I. S. Wollner, M. K. Cochran, and W. P. Ensminger. Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.Cancer Res. 46:1499–1506 (1986).

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