Phenytoin is associated with increased risk of osteoporosis and fragility fractures in adult epileptic patients
Author:
Funder
National Center for Advancing Translational Sciences
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Orthopedics and Sports Medicine,General Medicine,Endocrinology, Diabetes and Metabolism
Link
https://link.springer.com/content/pdf/10.1007/s00774-023-01475-2.pdf
Reference27 articles.
1. Lee RH, Lyles KW, Colón-Emeric C (2010) A review of the effect of anticonvulsant medications on bone mineral density and fracture risk. Am J Geriatr Pharmacother 8:34–46. https://doi.org/10.1016/j.amjopharm.2010.02.003. (PMID: 20226391; PMCID: PMC3570810)
2. Ali II, Schuh L, Barkley GL, Gates JR (2004) Antiepileptic drugs and reduced bone mineral density. Epilepsy Behav 5:296–300. https://doi.org/10.1016/j.yebeh.2004.02.005. (PMID: 15145297)
3. Siniscalchi A, Murphy S, Cione E, Piro L, Sarro G, Gallelli L (2020) Antiepileptic drugs and bone health: current concepts. Psychopharmacol Bull 50:36–44 (PMID: 32508365; PMCID: PMC7255839)
4. Kanda J, Izumo N, Kobayashi Y, Onodera K, Shimakura T, Yamamoto N, Takahashi HE, Wakabayashi H (2017) Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in rats. Biomed Res 38:297–305. https://doi.org/10.2220/biomedres.38.297. (PMID: 29070779)
5. Simko J, Karesova I, Kremlacek J, Fekete S, Zimcikova E, Malakova J, Zivna H, Valis M, Palicka V (2016) The effect of lamotrigine and phenytoin on bone turnover and bone strength: a prospective study in Wistar rats. Epilepsy Res 128:113–118. https://doi.org/10.1016/j.eplepsyres.2016.10.005. (Epub 2016 Oct 24 PMID: 27838501)
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