Protective effect of hydrogen sulfide on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers

Author:

Chen Shan-wen,Zhu Jing,Zuo Shuai,Zhang Jun-ling,Chen Zi-yi,Chen Guo-wei,Wang Xin,Pan Yi-sheng,Liu Yu-cun,Wang Peng-yuan

Funder

China Health and Medical Development Foundation (Grant: Research on Surgical Infection Mechanism and Control).

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Immunology

Reference40 articles.

1. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9(11):799–809.

2. Lin N, Xu LF, Sun M. The protective effect of trefoil factor 3 on the intestinal tight junction barrier is mediated by toll-like receptor 2 via a PI3 K/Akt dependent mechanism. Biochem Biophys Res Commun. 2013;440(1):143–9.

3. Chen SW, Wang PY, Zhu J, Chen GW, Zhang JL, Chen ZY, Zuo S, Liu YC, Pan YS. Protective effect of 1,25-Dihydroxyvitamin D3 on lipopolysaccharide-induced intestinal epithelial tight Junction injury in Caco-2 cell monolayers. Inflammation. 2014;38:375e383.

4. Chen S, Zhu J, Chen G, Zuo S, Zhang J, Chen Z, et al. 1,25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-α induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway. Biochem Biophys Res Commun. 2015;. doi: 10.1016/j.bbrc.2015.03.125 (Epub ahead of print).

5. Zanardo RC, Brancaleone V, Distrutti E, et al. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J. 2006;20:2118–20.

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