Abstract
AbstractIn this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products—syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.
Funder
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
Comenius University in Bratislava
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Drug Discovery,Molecular Medicine
Cited by
1 articles.
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