Abstract
Introduction: The intestinal microbiome is a diagnostic indicator and therapeutic target for non-communicable diseases. The aim of this work is to test the relationship between arterial stiffness, elasticity, gut microbiota and inflammation markers in the patients with acute coronary syndrome.
Methods: Elastic properties of arteries were evaluated by non-invasive arteriography (Tensiomed, Hungary), and intestinal microbiota was studied with the determination of key representatives by routine culturing methodology using biochemical identification kits (LACHEMA, Czech Republic). The level of SIgA and cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The data obtained for the clinical experimental group of patients were compared with the results obtained for the control group.
Results: Obtained data demonstrated a strong correlation between intestinal colonization by Enterococcus faecalis and PPbr (r=0.98), AIbr (r=-0.99) and AIao (r=-0.99). Significant correlations were found for Escherichia coli (lac+) and PPbr indicators (r=-0.97), and for Klebsiella oxytoca and SBP (r=-0.95), the systolic area index of the volumetric curve (r=+0.99), and the index of the diastolic area of the volumetric curve (r=-0.99). Indexed areas of the volumetric curve were correlated with colonization of Streptococcus spp. (r=-0.9 and 0.9 for systolic and diastolic area, respectively). Blood pressure correlated with the consentration of Candida spp. (r=0.95).
Conclusion: Detected bacteria (E. faecalis, K. oxytoca), pro-inflammatory cytokines, and intestine level of SIgA correlated with increased arterial stiffness and elasticity observed in patients with acute coronary syndromes (ACS) might be used as a rationale for the prevention and individual treatment of ACS in the earlier stages of the disease.
Publisher
Danylo Halytskyi Lviv National Medical University
Subject
Molecular Medicine,General Medicine
Reference33 articles.
1. Noce A, Marrone G, Di Daniele F, Ottaviani E, Wilson Jones G, Bernini R et al. Impact of gut microbiota composition on onset and progression of chronic non-communicable diseases. Nutrients. 2019;11(5):1073.
2. Sankararaman S, Noriega K, Velayuthan S, Sferra T, Martindale R. Gut microbiome and its impact on obesity and obesity-related disorders. Current gastroenterology reports. 2023;25(2):31-44.
3. Zhao E, Tait C, Minacapelli CD, Catalano C, Rustgi VK. Circadian rhythm, the gut microbiome and metabolic disorders. Gastro Hep Advances. 2022;1(1):93-105.
4. Rahman MM, Islam F, Or-Rashid MH, Mamun AA, Rahaman MS, Islam MM et al. The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation. Frontiers in Cellular and Infection Microbiology. 2022;713.
5. Krasnikov AV, Lagoda OV, DIu B, Krotenkova MV, Dzhibaladze DN. Asymptomatic stenoses and thrombosis of carotid arteries: ultrasonic and hemodynamic aspects. Angiol. Angio surgery. 2004;4:17-21.