Affiliation:
1. Microbiology and Bioinformatics, UTD, Atal Bihari Vajpayee University, Bilaspur (CG), India
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains several variants like Delta,
Alpha, Beta and Omicron, that is linked to DNA methylation leading to lung cancers in humans. COVID-
19 wave 1 and wave 2 are highly effected all around the world. Nine genes are identied in SARS-CoV-2 virus showing
membrane protein with 669bp. The genes of normal and delta SARS COV-2 membrane proteins showed several mutations
which is shown some effect with Remidesvir followed by Osimertinib and Curcumin. Normal, Beta and Alfa varients has shown
in one branch. Delta varient (second wave) has shown in other branch which shown variation from rst wave. Methylation
frequency is 100% for PTGS2 followed by 77% for CDH1 for lung cancer. PTGS2 has shown good protein-protein interaction with
ESR1, CDH1, APC, PTEN etc that are related for the cause of lung cancer. APC mediated PTCS2 from proliferation differentiation
and survival can be controlled via drugs. The selected molecules like Remidesvir, Osimertinib and curcumin have shown control
of mutated PTGS2 proteins of lung cancer. Osimertinib and Remidesvir found best with PTGS2 proteins.
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